Helminthic therapy: improving mucosal barrier function
نویسندگان
چکیده
منابع مشابه
Helminthic therapy: improving mucosal barrier function.
The epidemiology of autoimmune diseases and helminth infections led to suggestions that helminths could improve inflammatory conditions, which was then tested using animal models. This has translated to clinical investigations aimed at the safe and controlled reintroduction of helminthic exposure to patients suffering from autoimmune diseases (so-called 'helminthic therapy') in an effort to mit...
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Sites of inflammation are associated with profound changes in tissue metabolism. Studies in vitro and in vivo have shown that the activation of the hypoxia-inducible factor (HIF) serves as an adaptive pathway for the resolution of inflammation associated with various murine disease models. The resolution of disease occurs, at least in part, through transcriptional regulation of non-classical ep...
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Autoimmune and inflammatory diseases represent a significant health burden, especially in affluent societies and that no cure exists for majority of these diseases. Medication can slow the disease's progression, but many of the drugs on the market have unpleasant side effects. Current research on parasitic worms (helminthes) has demonstrated a great potential for whole worms, their eggs or thei...
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ژورنال
عنوان ژورنال: Trends in Parasitology
سال: 2012
ISSN: 1471-4922
DOI: 10.1016/j.pt.2012.02.008